trophoblast

Building a Global Team of Teachers for Healthy Pregnancy, Birth & Baby

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Danc­ing Thru Preg­nancy®, Inc.

Women’s Health & Fit­ness Pro­grams
found­ed 1979
MISSION STATEMENT
Many impor­tant health issues for girls and women involve mat­ters of repro­duc­tive
health, child­bear­ing, fer­til­ity and aging. Research informs us that an active, healthy
lifestyle pro­vides a num­ber of ben­e­fits through­out a woman’s life span:

  • reduced dis­com­forts from preg­nancy, labor, birth, recov­ery & menopause
  • reduced risk of hyper­ten­sive dis­or­ders of preg­nancy and pre­ma­ture birth
  • poten­tially short­er active labor and reduced risk of cesare­an deliv­ery
  • more rapid return to joy­ful activ­i­ties, less excess weight fol­low­ing birth
  • moth­er-infant inter­ac­tion, lead­ing to infant psy­chomo­tor enhance­ment
  • reduced rates of obe­sity, car­dio­vas­cu­lar dis­ease, and type 2 dia­betes
  • reduc­tion of some can­cers, osteo­poro­sis, falls and loss of mus­cle mass
  • improved social sup­port, net­work­ing and stress man­age­ment skills
  • greater belief in one’s abil­ity to be strong and capa­ble (self-effi­ca­cy)

What is Fetal Programming?

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What is fetal pro­gram­ming? Every per­son liv­ing on earth was first exposed to a uter­ine envi­ron­ment that helped deter­mine their life­time health and devel­op­ment. The term for this phe­nom­e­non is fetal pro­gram­ming. It is a hot top­ic and deserves atten­tion.

Accept­ing the impor­tance of fetal pro­gram­ming places respon­si­bil­i­ty on the moth­er-to-be to do all she can to insure her body pro­vides nutri­ents and oxy­gen to her grow­ing infant while avoid­ing pos­si­ble risks and tox­ins. At the same time, genet­ic and envi­ron­men­tal fac­tors con­tribute great­ly to the poten­tial for some dis­or­ders and prob­lems that arise. Thus, we must be care­ful in assign­ing guide­lines for accept­able behav­ior or blame for poor out­comes to preg­nant women.

On the one hand, we can all see the neg­a­tive con­se­quences of some­thing like fetal alco­hol syndrome…clearly the result of mater­nal behav­ior. Is a preg­nant woman whose baby has been dam­aged in this way guilty of abuse?

But, what if a moth­er is obese, eats poor­ly and ends up with an infant with a dis­turbed metab­o­lism. Is this abuse? What if the moth­er has an infec­tion that results in cere­bral pal­sy? Or what if she lives near a high­way and invol­un­tar­i­ly inhales fumes that neg­a­tive­ly affect the pla­cen­ta?

How do you get a healthy baby? Of course, there are no guar­an­tees. There remain many unknown fac­tors that can affect the course and out­come of a preg­nan­cy. Some fac­tors we are aware of, such as avoid­ing cer­tain fumes or chem­i­cals.  There are some behav­iors we know can max­i­mize the poten­tial for a good out­come, such as eat­ing ade­quate pro­tein, aer­o­bic con­di­tion­ing and strength train­ing. [Note for new readers…lots of these fac­tors have been cov­ered in our pre­vi­ous posts.]

But, what about all the things we don’t know about?

If these goats eat the wrong grass, will they go into labor?

Here is a cau­tion­ary tale:  There is a species of goat that, if they eat a cer­tain type of skunk grass on day 14 (and only day 14) of preg­nan­cy, will not go into labor. Why? Plant tox­ins in this grass inter­fere with the devel­op­ment of a small por­tion of fetal brain, the par­aven­tric­u­lar nucle­us. This nucle­us is involved in the sig­nal­ing cycle of labor. With­out it, the moth­er will not go into labor!

What are the take-home mes­sages here?

  • Prob­a­bly no one is ever a per­fect fetus…too many pos­si­ble threats.
  • There are some threats we can avoid…being lazy, over-eat­ing, smok­ing.
  • There are some threats we can­not avoid, so we do the best we can.

Do the best you can by your baby…aerobic fit­ness, good nour­ish­ment, sleep, good hygiene and de-stress­ing your life.

Pregnancy Pathway, Pregnancy — Maternal Immunological Response

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Today: Mater­nal Immuno­log­i­cal Response…or…the Mother/Fetus Dance!

Maternal Immune Response During Pregnancy

Mater­nal Immune Response Dur­ing Preg­nan­cy

Back to work! Thank you for your fore­bear­ance while we wrote a chap­ter for a nurs­ing text­book!

Dur­ing the course of preg­nan­cy, the mother/fetus dance is ongo­ing. The mater­nal immune sys­tem and the tro­phoblast cells con­tin­ue to influ­ence each oth­er even beyond the implan­ta­tion.

Because the mother’s immune response mod­u­lates near the start of each trimester, the fetus is affect­ed to some degree and mounts a response, as well. For a long time it was thought that mater­nal and fetal DNA mate­r­i­al was not exchanged across the pla­cen­tal mem­brane, how­ev­er recent find­ings indi­cate that there is some exchange of mate­r­i­al. Thus, we all car­ry some por­tion of our mother’s DNA and our moth­er car­ries some of ours.

What is the impact of this chimeric effect? It depends on how well our DNA gets along!

How does this affect the fetus in utero? The fetus may be affect­ed by clot­ting issues. Depend­ing on mater­nal health sta­tus s/he may be sub­ject to a stronger or weak­er immune sys­tem.

How does this affect the moth­er? Women are more like­ly than men to devel­op autoim­mune dis­or­ders (preg­nan­cy play­ing a role here), and those who bear male off­spring are more like­ly than those who only have girls to have these dis­or­ders.

The maternal/fetal dance goes on.…

Be Prepared for Birth!

Be Pre­pared for Birth!

Pregnancy Pathway, Conception — Prior Sperm Exposure

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Today:  Sperm!!!

For com­plete graph­ic, see Feb. 5 or 23 post.

The mother's prior sperm exposure can affect her pregnancy.

The mother’s pri­or sperm expo­sure can affect her preg­nan­cy.

Not every sperm is your friend! Sperm expo­sure — like so many expo­sures — affects our immune sys­tem. Women who have babies with more than one father may be at risk for dis­or­ders of preg­nan­cy because the chal­lenges to their immune sys­tem have been exten­sive. And, very young women who become preg­nant are at increased risk of some dis­or­ders because they have had very lit­tle expo­sure to sperm.

In addi­tion, women who have pri­mar­i­ly and exten­sive­ly used bar­ri­er meth­ods of con­tra­cep­tion may be at risk for dis­or­ders for rea­sons sim­i­lar to young women with lit­tle expo­sure. Unlike women whose immune sys­tem has had too much chal­lenge due to preg­nan­cies by sev­er­al men, women with lit­tle expo­sure may not have a strong defense against for­eign DNA. Please do not take this as a rea­son to not use a con­dom — one of the bar­ri­er meth­ods along with a diaphragm and cer­vi­cal cap. Rather, if you use a bar­ri­er method of con­tra­cep­tion, keep in mind that your body’s adjust­ment to preg­nan­cy may take time.

For more infor­ma­tion on bar­ri­er meth­ods, to go the Amer­i­can Col­lege of Obste­tri­cians and Gyne­col­o­gists’ online pam­phlet: ACOG Pam­phlet on Bar­ri­er Con­tracetp­tion.

Anoth­er way sperm can affect the preg­nan­cy is that the com­bi­na­tion of the mother’s and father’s nat­ur­al immune respons­es may be strong against the tro­phoblast implan­ta­tion. This is not some­thing  you can know ahead of time. Also, women are eight times more like­ly than men to devel­op autoim­mune dis­or­ders. One rea­son may be the pre­na­tal expo­sure to for­eign DNA encoun­tered in preg­nan­cy.

Keep in mind that by get­ting good pre­na­tal care, exer­cise, suf­fi­cient rest, stress man­ag­ment and healthy nutri­tion, you do all with­in your pow­er to have a healthy preg­nan­cy. Your health care provider will deter­mine your risk fac­tors that may affect preg­nan­cy out­come and treat you in an appro­pri­ate man­ner.

Moms and babies enjoy exercise together!

Moms and babies enjoy exer­cise togeth­er!

Once your baby comes, there will be time to max­i­mize health for both of you. Exer­cis­ing togeth­er is great fun!

Get­ting there may require some patience, but the reward is well worth it.

When you are look­ing around for sperm, use your head. The same behav­ior that pro­tects you from infec­tions you nev­er want to get, pro­tects you from sperm you don’t real­ly want to meet. When the time comes to adopt some sperm, find out about it’s cre­den­tials!

Pregnancy Pathway, Preconditions — Genetics

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Please refer to Feb­ru­ary 5 entry for com­plete graph­ic. The Pre­con­di­tion we will dis­cuss today is Genet­ics.

bubblus_preconditions_-_genetics

There are genet­ic fac­tors total­ly out­side your con­trol that deter­mine things as sim­ple as your offspring’s hair or eye col­or, how the ear­lobe attach­es to the side of the head and whether or not s/he can roll the tongue. More com­plex things, such as a pre­dis­po­si­tion to types of can­cers, bleed­ing dis­or­ders or var­i­ous oth­er dis­eases, also have a genet­ic basis.

Because the male con­tributes the sex of the off­spring, once con­cep­tion hap­pens, the sex off the fetus is deter­mined — at least genet­i­cal­ly. But, it turns out not every­thing genet­ic is set in stone. In utero, hor­mone expo­sures may affect how male and female char­ac­ter­is­tics devel­op, so that some girls will be very girlie, some will be tomboys, and some may be gay. A sim­i­lar effect will influ­ence how boys devel­op.

Genet­ic, envi­ron­men­tal and behav­ioral pre­con­di­tions can be  inter­twined. Envi­ron­men­tal fac­tors can alter genes, caus­ing them to express pro­teins that would oth­er­wise be dor­mant. Like­wise, our behav­ior affects some of our genes. If we have a fam­i­ly propen­si­ty for heart dis­ease, but we eat a healthy diet, exer­cise and avoid risky behav­iors, we alter the impact of our genet­ic code.

Keep in mind that some things will be com­plete­ly deter­mined by genes. It is not rea­son­able to hope, for exam­ple, that our off­spring will be 6′5″ if both par­ents are short (or vice ver­sa). If the moth­er has “thrifty genes” — that is, genes that make it easy for her to gain weight — she may well do so dur­ing preg­nan­cy, even if she fol­lows a rea­son­ably healthy lifestyle. If the immune sys­tems of both par­ents have some sim­i­lar­i­ties, it may affect the mater­nal immune response to the implant­i­ng tro­phoblast cells, thus affect­ing the pla­cen­ta and, indeed, the entire preg­nan­cy.

So, how do we advise peo­ple who are think­ing of preg­nan­cy to pre­pare them­selves for a healthy preg­nan­cy genet­i­cal­ly? Sure­ly, to deter­mine all the poten­tial genet­ic pos­si­bil­i­ties is not fea­si­ble or afford­able at this point. Maybe in anoth­er cen­tu­ry! But, we can know some fac­tors:  Is there sick­le cell ane­mia in both fam­i­lies? Is there a Mediter­ranean type of sick­le cell dis­or­der? What about clot­ting fac­tors or dif­fer­ences in Rh? What about dis­eases or dis­or­ders that are not com­mon, like ALS? These are things that poten­tial par­ents may want to dis­cuss.

Like so much of life, we can’t know every­thing. There are no guar­an­tees. There is a lot to be learned still about human genes and how they work.

This blog has at its heart the notion that phys­i­cal activ­i­ty has tremen­dous ben­e­fits for moth­er and offspring…and for part­ners, too. How does the genet­ic com­po­nent affect this? First, pre­con­cep­tion fit­ness low­ers some risk fac­tors for moth­ers and babies. Sec­ond, each mother’s genes will make it eas­i­er or more dif­fi­cult for her to enjoy or ben­e­fit from the activ­i­ty of exer­cise. We appre­ci­ate this and encour­age young moms-to-be to find some­thing enjoy­able that you like doing and find peo­ple or sit­u­a­tions that sup­port you in being active now before you become preg­nant.

If you need assis­tance or advice, please go to www.dancingthrupregnancy.com (use the BlogRoll)

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